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Negative Mental Health Impact: Gastrointestinal Side Effects: Some people taking semaglutide may experience gastrointestinal side effects such as nausea, vomiting, diarrhea, or abdominal pain

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While the combination is generally considered safe, both medications can influence blood pressure and cardiovascular health differently

This was significantly higher than those taking the placebo pill and greater than three additional medications approved for long term use: phentermine or topiramate ER, bupropion or naltrexone SR, and lorcaserin HCl