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In the early stage of the syndrome, macrophages can be rapidly activated by microbial stimuli, which subsequently boost the detrimental inflammation by producing multiple cytokines and recruiting excess inflammatory cells to the lung

VDAC is not only related to ATP synthesis but is also involved in Bax binding to mitochondria for mitochondrial-mediated apoptosis 32,33

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Our in vitro findings corroborated in vivo data from a mouse xenograft model in which daily administration of BSO either as a single agent or in combination with E 2 significantly reduced tumor growth of MCF-7:2A cells

Mapp CE, Fryer AA, De Marzo N, Pozzato V, Padoan M, Boschetto P, Strange RC, Hemmingsen A and Spiteri MA

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