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Erythrocytes are filled with iron-containing hemoglobin, prone to oxidative stress, critical for ferroptosis, and contain GPX4, an important regulator of ferroptosis [78, 498]
The advent of potent anti-inflammatory agents with their strong effects on reducing annualized relapsed rates has advanced the concept of progression independent of relapse activity (PIRA) (Lublin et al., 2022)
Ozone therapy is safe, free of side effects and allergies, and patients can feel an improvement in their health after the first treatment
Tirzepatide, sold under the brand names Mounjaro (type 2 diabetes) and Zepbound (chronic weight management and obstructive sleep apnea), is a dual GIP/GLP-1 agonist
[18] Valproate's precise mechanism of action is unclear