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Nutrient combinations sensed by L-cell receptors potentiate GLP-1 secretion

CJC-1295 (no DAC), also called Modified GRF (1-29), has a half-life of approximately 30 minutes, which better mimics physiological GHRH pulses and preserves natural GH secretion patterns

10.1038/s41598-021-94595-6 68 MurakamiT.FujimotoH.InagakiN

C., Lee K

The other half were given weekly injections of increasing amounts of semaglutide: 0.25 mg for 4 weeks, then 0.5 mg for 4 weeks, and then 0.5 or 1 mg in the last week, depending on a doctors judgement

Furthermore, the MAMs region contains several key regulators, including MFN2, VDAC1, and IP3R