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Higher doses of semaglutide (2.4 mg weekly, Wegovy) have been specifically licensed for weight management in individuals with obesity, reflecting the medication's potent effects on appetite regulation

Best Alternative to Amazon One Medical GLP-1 Program Amazon's GLP-1 program is well-designed for a specific patient profile: insured patients in One Medical markets who want their weight loss treatment integrated into primary care and are comfortable with a more involved clinical onboarding process

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Gudbergsen H, Henriksen M, Waehrens EE, Overgaard A, Bliddal H, Christensen R, Boesen MP, Knop FKK, Astrup A, Rasmussen MU, Bartholdy C, Daugaard C, Bartels EM, Ellegaard K, Heitmann BL, Kristensen LE (2019) Effect of liraglutide on body weight and pain in patients with overweight and knee osteoarthritis: protocol for a randomised, double-blind, placebo-controlled, parallel-group, single-centre trial

Approved uses: While all are approved for type 2 diabetes, only some (semaglutide as Wegovy, liraglutide as Saxenda) are currently approved for weight management

In severe osteoarthritis, the limiting problem is often structural joint degeneration