Semaglutide was approved for diabetes in 2017 and for weight loss in 2021
35 Significant advances in pharmacological treatment have primarily focused on HFrEF, the current therapy for which is built on four key pillars: angiotensin receptorneprilysin inhibitor (ARNI) or, alternatively, ACE inhibitors or angiotensin receptor blockers
May 2025 Updates: Highmark Network Update: Utilization Management (UM) Update for Weight Loss Drugs Carriers continue to assess their standpoint surrounding coverage for GLP-1 medications to determine how Utilization Management policy may need to be structured
Recently, the EU began an investigation in GLP-1 weight loss medications like Wegovy and Ozempic for the potential risk of depression or suicidal thoughts
GLP-1 at the metabolic-cognitive interface: reward, affect, and memory
But the head-to-head data confirms that the two medications are not equivalent in their effects at therapeutic doses