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These criteria collectively distinguish coordinated tissue dynamics from coincidental injury

A person who tolerates 8mg with zero side effects and achieves 21% weight loss over 48 weeks has a better outcome than someone who pushes to 12mg, feels terrible for three months, and quits at week 16

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Osteoarthritis remains one of the leading causes of chronic pain and disability globally, says Jay Karri, Assistant Professor of Pain Medicine at the University of Maryland School of Medicine and lead author

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