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However, when she attempted to move up to 1.0 mg, the side effects - bloating, gas, and fatigue - became overwhelming
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GI issues are among the most common GLP-1 medication side effects, and low fiber intake is a major culprit behind bathroom troubles
A replacement beats risking degraded medication
By Route of Administration Parenteral (subcutaneous injection) delivery held the dominant route of administration position in 2025 as all high-dose, high-efficacy GLP-1 formulations currently approved for obesity management require injection for the delivery of drug quantities sufficient to achieve therapeutic plasma concentrations
Patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use GLP-1 receptor agonists due to thyroid C-cell tumor risk observed in animal studies
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