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Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes

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Mean change in body weight from baseline to Week 52 was a secondary endpoint.* Comparable weight reduction with RYBELSUS 14 mg vs Jardiance PIONEER 2 study design 1,3 In an open-label trial with a primary endpoint of mean change in A1C from baseline to 26 weeks, 822 adult patients with type 2 diabetes on metformin were randomized to RYBELSUS 14 mg (n=411) or Jardiance 25 mg (n=410), both once daily

This dual action on blood sugar control and appetite suppression makes GLP-1 an essential player in maintaining metabolic balance