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Advertisement - Members don't see this ad #4 Gastrointestinal side-effects: The most commonly reported side-effects of GLP-1 RAs are gastrointestinal, such as nausea, vomiting, and diarrhoea.7 In the SUSTAIN trial, 52% of patients reported gastrointestinal side-effects in those receiving semaglutide compared with 35% in the placebo group, resulting in discontinuation of medication in 14% and 8% of patients, respectively.11 Nausea and vomiting are explained by direct central effects of GLP-1 and delayed gastric emptying

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Patients should be counseled that traditional weight loss approaches will not eliminate lipedema fat but can improve overall metabolic health

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