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Pre-existing organ disease is widely treated as a hard contraindication
Some GI adjustment (mild nausea, fullness) is normal and passes within 2-4 weeks
STAT News reports that under normal circumstances the final decision would be made by FDA scientists, but its possible that Trump administration officials could intervene and overrule them
ClinicalTrials.gov does not list any active or completed IGF-1 LR3 efficacy or safety study
Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven
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