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Integration is justified when it refines the question from whether a model predicts to which mechanism is most consistent with a given failure profile, and when it can be reported in a way that clinicians can act on without over-interpretation [291, 459, 471]
DAT has the ability to induce the degradation of ferritin through lysosomal pathways, consequently impacting iron homeostasis regulated by the iron regulatory protein/iron-responsive element (IRP/IRE) system
The radioactivity in (lactate plus pyruvate) was determined after thin layer chromatography of the incubation mixture, and radioactivity in any carbon dioxide formed was also measured
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