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Main Research Findings 1) Intra-articular administration of AOD9604 was shown to improve cartilage regeneration in cases of collagenase-induced knee osteoarthritis

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Absorption Issues from GI Conditions and Surgery Other health issues can throw up similar roadblocks to B12 absorption, making long-term injection therapy the only effective solution

Any discomfort is easily treated with over-the-counter pain medication, allowing patients to jump back into their activities without hesitation

Hydroxocobalamin is the standard UK preparation, administered intramuscularly for conditions like pernicious anaemia and gastrointestinal malabsorption B12 acts as a cofactor in DNA synthesis, red blood cell formation, and nervous system function, supporting energy metabolism pathways Common side effects include injection site reactions, mild gastrointestinal upset, and temporary urine discolouration, with serious reactions being rare NHS access requires GP assessment with blood tests