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In a clinical trial in 42 individuals with type 2 diabetes, 300 mg of a chlorogenic acid-containing plant extract daily for four weeks significantly reduced fasting plasma glucose, C-reactive protein (CRP), and liver enzymes compared with placebo (Abidov 2006)

Retatrutide targets all three receptors (GLP-1, GIP, and glucagon) simultaneously, and Phase 2 data showed up to 24.2% weight loss at 48 weeks

Strength training is best because it helps preserve basal metabolic rate during weight loss

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Neuroscience 290 , 126137 (2015)