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But the drugs' effects on that hormone system mean that they don't just act on the gut

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Have you considered failing at something cheaper first

Comparison to Placebo: the weight loss results were significantly greater than those achieved by placebo groups, underscoring its efficacy in managing obesity and overweight conditions (Lilly Investor Relations)

Other studies also showed that tamoxifen attenuates tumor growth in a xenograft model with ER-negative MDA-MB-468 human breast cancer cells

You should also disclose any other medications you're taking, especially if your healthcare team decides to postpone GLP-1 use to perform surgery