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Ghrelin exerts its effects primarily through Growth Hormone Secretagogue Receptor 1a (GHS-R1a), a GPCR predominantly found in the pituitary gland, ARC, VMN, and PVN of the brain, as well as in various other tissues including pancreas, spleen, heart, kidneys, gonads, thyroid gland, adrenal glands, adipose tissue, and vascular systems [27] [28]

PMID 21640828

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