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Conducted by trial, data from each of the seven trials were stratified into two subgroups, subjects receiving metformin at baseline and subjects with no metformin at baseline (metformin/no-metformin), to evaluate the differences in treatment effect on CV outcomes according to baseline metformin use
The before and after results for men and weight loss results overall vary by individual factors, not by sex-based pharmacokinetic differences
But is one better than the other
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