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As the ROS levels are very low in FISCs from both Keap1 +/- and Keap1 -/- mice 25,30 (Supplementary Fig

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Endothelial cells (ECs) covering the inner surface of the vascular wall can generate, activate, and release various vasoactive substances and regulate cardiovascular function, including nitric oxide (NO), prostacyclin (PGI2), endothelin-1 (ET-1), and endothelium-derived contracting factors (EDCF)