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In rodents, this behavior can be studied in the operant self-administration model (Sanchis-Segura and Spanagel, 2006)
doi: 10.1006/bbrc.2000.3342 251 SeoaneLMTovarSBaldelliRArvatEGhigoECasanuevaFFet al
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[6] These findings support the interpretation that NO-related pathways may contribute to some observed BPC-157-associated effects in laboratory systems, but they do not prove that BPC-157 directly binds NOS enzymes or directly controls NO production
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