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The clinical efficacy of edaravone has been thoroughly reviewed elsewhere (Halliwell and Gutteridge, 2015
In principle, a hyperoxidizing ER might simply blunt the UPR rather than improve ER function, since activation of at least the UPR sensors ATF6 and IRE1 can be inhibited by oxidation (Nadanaka, Okada, Yoshida, & Mori, 2007
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REFERENCE: Goswami A, Rosenberg I
however, the L-carnitine-induced upregulation of CPT1 has been shown to prevent inflammation by decreasing inflammatory cytokines, such as TNF-, in serum and the liver 30,35