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In a randomized, double-blind, placebo controlled trial performed on 369 participants with DPN, capsaicin 8% patch treatment provided modest pain relief and sleep quality improvements versus a placebo patch [142]

Prog Lipid Res 49:6175 Marcovina SM, Sirtori C, Peracino A, Gheorghiade M, Borum P, Remuzzi G, Ardehali H (2013) Translating the basic knowledge of mitochondrial functions to metabolic therapy: role of l-carnitine

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