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For many years clinicians and experimentalists who work on one-carbon metabolism have said that homocysteine is a good biomarker for vitamin deficiencies

89,107 However, a novel strategy has evolved in which the active agent delivers its positive effects in the dermal layers, but then is metabolized to an inactive state once it reaches the blood circulation

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For examining the efficacy of IKE, after the size of the tumors reached around 100 mm 3 , mice were randomized into three groups (six mice per group): 1) Vehicle group with vehicle A (5% DMSO, 95% corn oil) (oral gavage) every three days and daily i.p