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Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers Acta Psychiatr Scand 1997

Muscle loss reduces metabolic rate, which deepens fatigue, which reduces motivation to eat, which worsens the deficit further

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Dysbiosis Imbalances in the microbiome may promote metabolic disturbances through altered microbial metabolism and inflammatory signaling