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If a hypersensitivity reaction is suspected, discontinue Janumet, assess for other potential causes for the event, and institute alternative treatment for diabetes
On a 50-unit dose, it barely matters
Fatigue may occur temporarily due to appetite changes and metabolic adjustment
PMID 17404387
The histidine residue serves as the primary copper-binding site through its imidazole ring, creating a stable square-planar copper(II) complex with the amino terminal and adjacent peptide nitrogen atoms