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The therapeutic actions of ibuprofen are mediated by its ability to inhibit the synthesis and release of prostaglandins (PGs) E2 (PGE2) and I2 (PGI2) by blocking cyclooxygenase (COX) enzymes COX-1 and COX-2 which are involved in the generation of pain, fever, and inflammation 2,3

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Prevalence and co-prevalence of comorbidities among patients with type 2 diabetes mellitus