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In the LEADER trial, patients with type 2 diabetes at high cardiovascular risk who received liraglutide experienced a 13% reduction in major adverse cardiovascular events (MACE), a combined measure of heart attack, stroke, or cardiovascular death
Those who switched to a combination of DPP4i and SGLT2i maintained stable glucose levels, although the small sample size limits definitive conclusions
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Cell 24 , 649659 (2013)
In addition, some of these drugs side effects are more severe and widespread than originally believed or disclosed to users: A study published by the National Center for Biotechnology Information reported that instances of intestinal obstruction were 4.5x higher for GLP-1 receptor agonists like Ozempic and Wegovy than for other glucose control medications
JAMA Ophthalmol 2024;142:7329
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