Subsequent motif analysis confirmed that the promotors of GPX4 , GSS , NFE2L2 , ATG3 , and ATG4D contain multiple ATF4 binding sites, and the basic sequences of the binding sites were consistent with the reported motif for ATF4
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The glutathione can then be degraded by the cytoplasmic ChaC family of -glutamylamine cyclotransferases [ChaC1 (ChaC glutathione specific gamma-glutamylcyclotransferase 1) and ChaC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2)] generating 5-oxoproline and the dipeptide Cys-Gly
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