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Cytosolic ferritin (binds up to 4,500 iron atoms for storage) may be a source of free iron when it undergoes degradation in response to stress (reviewed in Philpott et al., 2017)

Historically, these patients have been told that they just have hemorrhoids

Medications were discontinued when pregnancy was confirmed

Lower scores are better , thus the authors considered this data as potential evidence supporting slowing of disease progression

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Microbiota-derived tryptophan metabolites indole-3-lactic acid is associated with intestinal ischemia/reperfusion injury via positive regulation of YAP and Nrf2