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For multiple imputed datasets, matching and statistical analyses were performed separately on each resultant dataset, and the statistical estimates were finally pooled
Though the clinical significance has not been clearly established, notable changes (increases and decreases) from baseline in blood pressure and pulse rate were observed more commonly in pediatric patients treated with topiramate compared to those treated with placebo during migraine prophylaxis trials
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2013 Mar 8;288(10):7137-46
