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11 Exenatide has been associated with hypoglycemia when given in combination with metformin, SUs, and TZDs

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Concurrently, PPIs, frequently prescribed to diabetic patients for gastroesophageal reflux disease management, impair protein-bound vitamin B12 release from dietary sources in the non-acidic gastric environment, with prolonged use ( 2 years) conferring a 65% increased risk of deficiency [159]

En el metaanlisis de Sattar antes mencionado el objetivo renal compuesto de deterioro de la funcin renal, necesidad de tratamiento sustitutivo renal, muerte renal y desarrollo de macroalbuminuria se redujo en un 21% (HR 0,79, IC 95%: 0,73-0,87

The American Diabetes Association recommends starting GLP-1 medications at the lowest dose and titrating gradually to minimize side effects

Lee SM, Hay DL, Pioszak AA