If further weight loss is needed and the medication is well-tolerated, the dose can be increased in 2.5 mg increments (to 7.5 mg, 10 mg, 12.5 mg, and up to the maximum of 15 mg once weekly for Zepbound) generally every 4 weeks
Nausea usually subsides significantly after 46 weeks, though some individuals notice mild queasiness for longer depending on their dose titration schedule and genetic sensitivity
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Jesper Lau, Paw Bloch, and Thomas Kruse Hansen are listed as inventors