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The FDA approval is based on the OASIS 4 Phase 3 clinical trial a 64-week study of 307 adults with obesity or overweight and at least one weight-related health condition (such as high blood pressure, high cholesterol, or prediabetes), but without type 2 diabetes
GLP-1RAs have been shown to improve diabetes, promote weight loss, and reduce hepatic fat content (Yao et al., 2024)
Artificial sweeteners do not raise blood sugar but may increase cravings for sweet foods in certain individuals
Potential Benefits: Enhanced Mitochondrial Function: Supports the health and efficiency of mitochondria, promoting increased energy levels and stamina
Retatrutide Clinical Studies Registry
This decision affected some of the most vulnerable patients, those who could least afford to pay out of pocket for medications costing $1,000 or more per month
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