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Shape engineering, such as rod-like versus spherical particles, can enhance membrane contact and cellular uptake, while stimuli-responsive materials (e.g., ROS- or pH-sensitive polymers) enable on-demand drug release at RIRI lesions, reducing off-target effects
For example, US distributor McKesson reported an incredible $14 billion in GLP-1 revenue in a single quarter, yet they earn a mere 1-2% fee-for-service
Limitations of an open-label study may be related to a bias in evaluation of the outcomes, efficacy and/or safety, and analysis was not tested against a placebo-controlled comparison group 1
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