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In the dimeric COP1-DDD-E2 complex, the WD40 domains of COP1 are orientated toward each other and separated by a distance of approximately 20

They work, and they're well-regulated

It was found that while inhibition of PGE 1 further increased the levels of certain cytokines in serum and peritoneal fluid [45], inhibition of PGE 2 reversed these values toward that of control [46]

I must admit that I was unsure if this would work but i am so happy with the results so far