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Some individuals may be more sensitive to the medication and require a smaller, more gradual increase in dosage to manage side effects

If elimination pathways are impaired, these compounds may be reabsorbed into circulation rather than fully excreted

If nausea arises when GLP-1 RA plasma concentrations are at their peak, then continuous exposure to GLP-1 RAs may lead to tachyphylaxisa reduced response to the drug over timeresulting in fewer gastrointestinal symptoms after long-term use [20]

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You can layer the two by applying the thinnest layer first but this can increase the risk of irritation