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For a typical bioenergetic profile, a set of inhibitors of key components of cellular respiration was added: 24 g/mL oligomycin A, 0.8 M of the uncoupler FCCP and a mix of 5 M rotenone and 15 M antimycin A

In previous studies, the expansion of polyglutamine (polyQ) bundles to 36 or more glutamine repeats will cause the HTT protein to misfold and aggregate, leading to neuronal death and symptoms of Huntingtons disease (Mangiarini et al., 1996)

It is a leading cause of cardiovascular disease, end-stage renal disease and blindness, causing a relevant economic impact on patients, their families and the health care system 1

Not big weight loss

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