Specific dysfunctions in energy producing pathways in ALS Under normal physiological conditions, glucose is the main energy substrate for neuronal tissue and a major fuel for muscles
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Another is failing to update the diagnosis when the patients weight changes over time
Thus, if a patient does not respond well to a GLP-1 agonist, possibly reflecting dysfunction within downstream neural/endocrinological circuits, stimulating different upstream receptors that feed into the same effector system is unlikely to produce a materially better response
Alternatives for microdosing GLP-1 medications include a slower titration phase, switching to a different medication, or managing the side effects with lifestyle modifications