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Recent advancements in LOX inhibitors as anti-inflammatory medicines have concentrated on their efficacy, structureactivity connections, and molecular docking analyses, offering novel pathways for therapeutic development [276]
J Proteome Res 2013
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Moreover, oxidative damage to mitochondrial DNA (mtDNA) results in the release of mtDNA into the cytosol, where it triggers Toll-like receptor 9 (TLR9) and inflammasome activation, leading to further production of pro-inflammatory cytokines and recruitment of immune cells 67
