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doi: 10.1152/ajpendo.00006.2020
KPV is most often discussed in relation to gut health because of research in intestinal epithelial cells, immune cells, and colitis models
FoxO1, a downstream target of the PI3K/Akt pathway, is phosphorylated by Akt and retained in the cytoplasm, thereby preventing its inhibition of target gene expression in the nucleus of POMC neurons [17]
The relationship is not definitively established as causal
One large observational study found higher risk for diabetes in younger adults with low IGF-1, but not in adults older than 65
& Rhodes, A
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