Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants
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In the latest JAMA Medical News podcast, Jennifer Abbasi interviews Rita Kalyani, MD, about investigational therapies including retatrutide, a triple agonist showing high efficacy for glycemic control and weight loss, and new oral options like orforglipron
The choice between them involves factors beyond just weight loss efficacy, including side effect profiles , cost, availability, and individual metabolic considerations
Recent advancements have led to the development of oral GLP-1 RAs, broadening their clinical applications