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Known GLP-1 side effects include: nausea, vomiting, diarrhea, dizziness, increased heart rate, infections, headaches, indigestion, pancreatitis, medullary thyroid cancer, sudden kidney injury, worsening diabetic-related retinopathy, shortness of breath, wheezing, hives, difficulty swallowing, rash, abdominal pain and feelings of doom or dread

Benton, D., & Donohoe, R.T

Others, including some antidepressants and antidiabetic agents, may enhance metformin's blood sugar-lowering effect, which can raise the risk of hypoglycemia

Pancreatitis is an uncommon but serious adverse effect associated with GLP-1 receptor agonists (occurring in approximately 0.10.2% of patients)

Further, the analyses in this trial were conducted on the ITT sample and applied the last observation carried forward (LOCF) principle which may have biased the trial level results in favor of phentermine 15 mg/topiramate 92 mg

Most protocols at The Good Life IV use either subcutaneous injection or topical application depending on the goal