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Taken together, the ISR and cAMP findings support the hypothesis that GLP-1R-mediated increases in cAMP potentiate insulin secretion, but that simultaneous occupation of Y1-R prevents binding to GLP-1R and/or the capacity to elicit relevant downstream responses
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Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer
Pricing was set at $149 per month for self-pay patients, $25 with commercial insurance, and $50 for Medicare beneficiaries starting July 1
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