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Early evidence suggests GLP-1 medications may also reduce neuroinflammation, which has been linked to disrupted sleep regulation in individuals with metabolic disease (ref, ref)
(Skip ahead if you already understand all this.) Your body regulates the amount of glucose in the blood through a complex system of negative feedback loops
Enter glutathione, universally recognized in the medical community as the "master intracellular antioxidant." While healthy bodies naturally synthesize enough of this vital compound to neutralize daily metabolic waste, the immense inflammatory burden of complex chronic illnesses can overwhelm these built-in systems
Although rare, metformin may cause lactic acidosis
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Much of the field is now being built on multi-mechanism approaches: tirzepatide combining GLP-1 and GIP, retatrutide adding glucagon to that mix, and cagrilintide plus semaglutide taking yet another route to polyagonism
