Direct injection of 1 nmol GLP-1, exendin-4, or liraglutide to the ARC significantly suppressed food intake and body weight, with the effects observed over the 24 hours following injection [71,79,80]
Comparative work with selective MC4R agonists (bremelanotide) and selective MC3R agonists helps dissect the individual contributions of these receptor subtypes to integrated energy balance regulation
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doi: 10.1016/S1472-6483(10)60346-X 54 AltunTJindalSGreenseidKShuJLP