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Such approaches greatly affect the generalizability of study results to real-world settings and raise concerns about the validity of projecting the results to long-term outcomes
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If your team isnt ready yet to cover GLP-1s for weight loss, simply covering low-cost alternative oral weight loss medications is completely acceptable and still can provide successful clinical outcomes
For example, if you normally inject on Monday but need flexibility, you could move your injection day to Tuesday or Wednesday for that week only, then resume your original Monday schedule the following week
To date, GLP-1 RAs have demonstrated efficacy in obese patients with HFpEF, but data in HFrEF remain scarce
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