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Activation of the GLP-1 and GIP pathways is associated with improved glycaemic control and reduced energy intake, whilst the role of the glucagon receptor is being investigated in relation to increased energy expenditure and lipid metabolism

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Key end points included: hospitalisation, heart failure (ICD-10-CM-I50), myocardial infarction (ICD-10-CM-I21), stroke and transient ischaemic attack (ICD-10-CM-I63, G45), development of diabetic microvascular complications (ICD-10-CM-E10.210.4) and all-cause mortality analysed 3 months to 5 years post drug initiation

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Tras evaluar el riesgo de MACE a las 20 y 104 semanas de iniciado el tratamiento, los autores descubrieron que las personas con sobrepeso moderado experimentaron beneficios similares a los registrados entre quienes tenan ndices de masa corporal ms altos

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Phase 3 TRIUMPH trials The most recent data comes from the phase 3 program

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