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The mechanism involves upregulation of tissue inhibitors of metalloproteinases (TIMPs) and simultaneous downregulation of matrix metalloproteinases (MMPs), shifting the extracellular matrix balance toward net deposition rather than degradation

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One small study of patients with early, untreated Parkinsons disease given high dose intravenous glutathione twice a day for 30 days showed symptom improvement that lasted for 2-4 months after treatment ended

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However, the dose and frequency for glutathione can vary from person to person according to their needs