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Furthermore, hydroxyalanine has emerged as a prospective marker for diagnosing psoriatic arthritis (103), while variations in levels of circulating metabolites are correlated with the activity and severity of the condition (121, 122)

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In vitro experiments demonstrated that Akt inhibition markedly upregulated the expression of FTL, FTH, TFR1, and Poly (rC)-binding protein 1 (PCBP1), downregulated FPN1 expression, increased APP expression, enhanced iron storage and uptake, and decreased iron efflux, thereby aggravating neurological injury in SH-SY5Y and C2C12 cells (Halon-Golabek et al., 2024)

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