That is a genetic-knockdown study in mice, not a drug trial: it tells you the target is real and metabolically meaningful in an animal model, but it does not test a drug, a dose, or a route
Recent advancements in the nano-encapsulation of curcumin have established a method to enhance its stability and solubility in aqueous environments, facilitating its delivery to various cellular compartments, particularly inner ear cells, that are primarily affected by cisplatin ototoxicity (Aggarwal and Sung 2009
MMPs are enzymes that break down the extracellular matrix necessary for remodeling damaged tissue, but problematic when elevated chronically
Huang H et al
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