Thirdly, inflammatory signaling: In myocardial infarction models, TMAO activates JAK2-STAT3 in cardiac fibroblasts, increasing JAK2/STAT3 phosphorylation and fibronectin/collagen I/III synthesis (Yang et al., 2025)
In general, GPX4 (glutathione peroxidase 4) is a typical member in GPx (total glutathione peroxidases) family and acts as an antioxidant protein with glutathione peroxidase activity to suppress phospholipid oxidation and ROS (reactive oxygen species) production to suppress ferroptosis 49,50,51,52
In the past, there has been controversy regarding the interaction of NFT with glutathione (Silva et al
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doi: 10.1016/j.chemosphere.2019.125691 16 CohenS
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